One of the most promising strategies for successfully designing complex biomolecular functions is to exploit nature's principles of evolution. This course provides an overview of the basics of molecular evolution as well as its experimental application to the engineering of proteins, DNA, and RNA with functions of therapeutic, scientific, or economic value. The course will cover the generation of diversity (e.g., mutagenesis and DNA shuffling), the coupling of genotype and phenotype (e.g., surface display of proteins and peptides), and methods for screening and selection.

Course prerequisites: 

Junior standing and a basic understanding of recombinant DNA technology.

Course instructor: