In this graduate-level course, we will cover important principles in thermodynamics and kinetics along with examples relevant to engineering practice. After a short review of the first and second laws of thermodynamics, we will move on to their application in engines and refrigeration. We will discuss the thermodynamic properties of systems consisting of pure species and mixtures and address phase equilibria. With the key thermodynamic concepts in place, we will discuss topics in kinetics, including the fundamentals of reaction rates, rate laws, multiple reactions, and nonelementary reaction kinetics. Finally, we will address how reactor type and properties, transport limitations, and phase equilibria influence reaction rate.