This course introduces statistical analyses and techniques of experimental design appropriate for use in environmental applications. The methods taught in this course allow the experimenter to discriminate between real effects and experimental error in systems that are inherently noisy. Statistically designed experimental programs typically test many variables simultaneously and are very efficient tools for developing empirical mathematical models that accurately describe physical and chemical processes. They are readily applied to production plant, pilot plant, and laboratory systems. Topics covered include fundamental statistics; the statistical basis for recognizing real effects in noisy data; statistical tests and reference distributions; analysis of variance; construction, application, and analysis of factorial and fractional-factorial designs; screening designs; response surface and optimization methods; and applications to pilot plant and waste treatment operations. Particular emphasis is placed on analysis of variance, prediction intervals, and control charting for determining statistical significance as currently required by federal regulations for environmental monitoring.