Technical managers, systems engineers, lead engineers, and mission assurance professionals will benefit from this course, which focuses on the leadership of system safety and mission assurance activities throughout the life cycle of a project to achieve mission success. This advanced course provides crucial lessons learned and proven best practices that technical managers need to know to be successful. The integrated application of mission assurance and systems engineering principles and techniques is presented in the context of aerospace programs and is also applicable to other advanced technology research and development programs. Students discuss critical risk-based decision making required from system concept definition and degree auditing through design, procurement, manufacturing, integration and test, launch, and mission operations. Experiences shared by senior aerospace leaders and extensive case studies of actual mishaps explore quality management topics relevant to aircraft, missiles, launch vehicles, satellites, and space vehicles. The course addresses contemporary leadership themes, government policies, and aerospace industry trends in mission assurance requirements, organizational structure, knowledge sharing and communication, independent review, audit, and assessment. Mission assurance disciplines covered include risk management, system safety, reliability engineering, software assurance, supply chain management, parts and materials, configuration management, requirements verification and validation, non-conformance, and anomaly tracking and trending.