This course is an interdisciplinary approach to the concepts, principals, computational methods, and algorithms used in structural bioinformatics. It focuses on the fundamental aspects of structural biology along with computational methods and algorithms for studying protein folding, structure prediction, and analysis. Algorithms for the prediction and annotation of protein secondary and tertiary structure and for structure-structure comparison will be studied in depth. We will also show how such algorithms and methods can be adapted for use with nucleic acids structure prediction and analysis. Students will apply various software tools and structure-visualization software to protein structure prediction and structure-structure comparison.

Course prerequisite(s): 

605.205 Molecular Biology for Computer Scientists or equivalent. 605.651 Principles of Bioinformatics is recommended.

Course instructor(s): 

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