During the last decade, systems biology has emerged as an effective tool for investigation of complex biological problems, placing emphasis on the analysis of large-scale data sets and quantitative treatment of experimental results. In this course, students will explore recent advances in systems biology analysis of intracellular processes. Examples of modeling and experimental studies of metabolic, genetic, signal transduction, and cell cycle regulation networks will be studied in detail. The classes will alternate between consideration of network-driven and network element (gene, metabolite, or protein)-driven approaches. Students will learn to use Boolean, differential equations, and stochastic methods of analysis and will become acquainted with several powerful experimental techniques, including basics of microfabrication and microfluidics. For their course projects, students will develop models of a signal transduction or metabolic pathway.
Courses in molecular biology (605.205 Molecular Biology for Computer Scientists or 410.602 Molecular Biology and differential equations.