Systems biology is the study of complex biological systems using theoretical, mathematical, and computational tools and concepts. The advent of genomics, big data, and high-powered computing is allowing better understanding and elucidation of these systems. Central to systems biology is the development of computational models, based on sounds statistics, which incorporate biological structures and networks, and can be informed and tested, with data on multiple scales. In this class, students will learn to develop and use different types of models of complex biological systems, and how to test and perturb them. Students will learn basic biological system components and dynamics, as well as the data formats, sources, and modeling tools required to interrogate them. Tools will be used relating to functional genomics, evolution, biochemical systems, and cell biology. Students will utilize a model they have developed, and available data from public repositories to investigate both a discovery-based project, and a hypothesis-based project.
Courses in molecular biology (605.205 Molecular Biology for Computer Scientists or 410.602 Molecular Biology and differential equations.