This course examines how artificial intelligence is reshaping human relationships in areas that have traditionally relied on human presence—such as companionship, teaching, therapy, management, and collaboration. Students will explore when AI enhances human connection and when it substitutes for or undermines it. Topics include AI companions and the “loneliness economy,” mental health apps and therapeutic chatbots, educational AI and the nature of effective teaching, and AI in workplace relationships, including algorithmic management, performance monitoring, and HR systems. The course also considers emerging technologies such as prediction markets that turn everyday human events into tradable assets. Throughout, students will analyze the ethical, social, and design implications of AI in relational settings. The course draws on interdisciplinary perspectives from ethics, philosophy, labor studies, and science and technology studies. Engineering and computer science students will gain tools for understanding the human contexts their technologies enter and for evaluating how design choices shape whether AI supports or exploits users. Students interested in AI leadership will develop frameworks for assessing technologies used in areas such as employee wellness, coaching, customer service, and education, with attention to both their benefits and potential risks.