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This course focuses on the application of engineering fundamentals along with concepts and techniques from molecular cell biology and biophysics to understand normal physiology and pathological disorders. Class lectures will include an overview of molecular cell biology principles and engineering approaches to cell biology, an extensive discussion on extracellular matrix, cell cytoskeleton and basics of adhesion molecules, followed by topics on cell-cell and cell-matrix interactions from both experimental and theoretical perspectives. Lectures will also cover the effects of physical (e.g. fluid shear stress, confinement), chemical (e.g. growth factors) and electrical cues on cell function, emphasizing topics on gene regulation and signal transduction processes. Moreover, topics in cancer metastasis and current therapeutic strategies will be discussed.