Fundamental concepts in drug delivery from an engineering perspective. Biological organisms are viewed as highly interconnected networks where the surfaces/interfaces can be activated or altered “chemically” and “physically/mechanically.” The importance of intermolecular and interfacial interactions on drug delivery carriers is the focal point of this course. Topics include drug delivery mechanisms (passive, targeted); therapeutic modalities and mechanisms of action; engineering principles of controlled release and quantitative understanding of drug transport (diffusion, convection); effects of electrostatics, macromolecular conformation, and molecular dynamics on interfacial interactions; thermodynamic principles of selfassembly; chemical and physical characteristics of delivery molecules and assemblies (polymer based, lipid based); significance of biodistributions and pharmacokinetic models; toxicity issues; and immune responses.