Modeling Approaches to Cell and Tissue Engineering - 585.743

Through lectures, quizzes, mathematical /computational projects, and assignments, this course presents the main modeling approaches, such as cell- and rule-based methods, to cell and tissue engineering. This course covers the topics of cancer (tumor development and treatment), bone (bone fracture healing and use of implants), and skeletal muscle regeneration (after major volume losses). In each case, a multicellular system us considered where several groups of cells divide, migrate, differentiate and dye. In addition, these cells interact with the microenvironment, including the extracellular matrix whose mechanical properties, stiffness, and stress relaxation time have effects on the cell’s fate. This course will be an effective tool for design and optimization of scaffolds, implants, and materials in regenerative medicine.