This course focuses on current problems of computational genomics. Students will explore bioinformatics software, discuss bioinformatics research, and learn the principles underlying a variety of bioinformatics algorithms. The emphasis is on algorithms that use probabilistic and statistical approaches. Topics include analyzing eukaryotic, bacterial, and viral genes and genomes, genome sequencing and assembling, finding genes in genomes and identifying their biological functions, predicting regulatory sites, and assessing gene and genome evolution. Prerequisite(s): EN.605.205 Molecular Biology for Computer Scientists or equivalent and familiarity with probability and statistics.