Anton Dmitriev

Education History

• BS, Biology, Towson, University
• M Sc, Applied Biomedical Engineering, Johns Hopkins University
• Ph D, Neuroscience, Uniformed Services University of the Health Sciences F. Edwards Hebert School of Medicine

Work Experience

Director, Division of Applied Mechanics, OSEL/CDRH, U.S. Food and Drug Administration

Publications

1) Shimamoto N, Cunningham BW, Dmitriev AE. Biomechanical Evaluation of Stand-Alone Interbody Fusion Cages in the Cervical Spine. Spine 2001; 26: E432-E436.

2) Cunningham BW, Shimamoto N, Sefter JC, Dmitriev AE, Orbegoso CM, McCarthy EF, Fedder IL, McAfee PC. Osseointegration of Autograft Versus Osteogenic Protein-1 in Posterolateral Spinal Arthrodesis: Emphasis on the Comparative Mechanisms of Bone Induction. The Spine Journal 2002; 2: 11-24.

3) Cunningham BW, Orbegoso CM, Dmitriev AE, Hallab NJ, Sefter JC, McAfee PC. The Effect of Titanium Particulate on Development and Maintenance of a Posterolateral Spinal Arthrodesis: An In-Vivo Rabbit Model. Spine 2002; 27(18): 1971-1981.

4) Cunningham BW, Lewis SJ, Long J, Dmitriev AE, Linville DA, Bridwell KH. Biomechanical Evaluation of the Lumbosacral Reconstruction Techniques for Spondylolisthesis: An In-Vitro Porcine Model. Spine 2002 Nov 1; 27(21):2321-7.
5) Lebwohl NH, Cunningham BW, Dmitriev A, Shimamoto N, Gooch L, Devlin V, Boachie-Adjei O, Wagner TA. Biomechanical Comparison of Lumbosacral Fixation Techniques in a Calf Spine Model. Spine 2002 Nov 1; 27(21): 2312-20.

6) Cunningham BW, Lowery GL, Serhan HA, Dmitriev AE, Orbegoso CM, McAfee PC, Fraser RD, Ross RE, Kulkarni SS. Total Disc Replacement Arthroplasty Using the Acroflex Total Disc: a Non-Human Primate Model. Eur Spine J. 2002 Oct, 11 Suppl 2: S115-23.

7) Cunningham BW, Orbegoso CM, Dmitriev AE, Hallab NJ, Sefter JC, Asdourian P, McAfee PC. The Effect of Spinal Instrumentation Particulate Wear Debris: An In Vivo Rabbit Model and Applied Clinical Study of Retrieved Instrumentation Cases. The Spine J. 2003 Jan, 3(1): 19-32.

8) Cunningham BW, Orbegoso CM, Dmitriev AE, Hallab NJ. The Effect of Titanium Particulate on Development and Maintenance of a Posterolateral Spinal Arthrodesis: an In Vivo Rabbit Model. Spine. 2002 Sep 15;27(18):1971-81.

9) McAfee PC, Cunningham BW, Orbegoso CM, Sefter JC, Dmitriev AE, Fedder IL. Analysis of Porous Ingrowth in Intervertebral Disc Prostheses: a Non-Human Primate Model. Spine. 2003 Feb 15;28(4):332-40.

10) Cunningham BW, Gordon JD, Dmitriev AE, Hu N, McAfee PC. Biomechanical Evaluation of Total Disc Replacement Arthroplasty: an In Vitro Human Cadaveric Model. Spine. 2003 Oct 15;28(20):S110-7.

11) Cunningham BW, Dmitriev AE, Hu N, McAfee PC. General Principles of Total Disc Replacement Arthroplasty: Seventeen Cases in a Non-Human Primate Model. Spine. 2003 Oct 15;28(20):S118-24.

12) McAfee PC, Cunningham BW, Dmitriev AE, Hu N, Woo Kim S, Cappuccino A, Pimenta L. Cervical Disc Replacement – Porous Coated Motion Prosthesis: a Comparative Biomechanical Analysis Showing The Key Role of The Posterior Longitudinal Ligament. Spine. 2003 Oct 15;28(20):S176-85.

13) Jahng TA, Fu TS, Cunningham BW, Dmitriev AE, Kim DH. Endoscopic Instrumented Posterolateral Lumbar Fusion with Healos and Recombinant Human Growth/Differentiation Factor-5. Neurosurgery. 2004 Jan; 54(1): 171-181.

14) Kotani Y, Cunningham BW, Abumi K, Dmitriev AE, Ito M, Hu N, Shikinami Y, McAfee PC, Minami A. Multidirectional flexibility analysis of cervical artificial disc reconstruction: in vitro human cadaveric spine model. J Neurosurg Spine. 2005 Feb;2(2):188-94.

15) Dmitriev AE, Cunningham BW, Hu N, Sell G, Vigna F, McAfee PC. Adjacent Level Intradiscal Pressures Following a Cervical Total Disc Replacement Arthroplasty. An In-Vitro Human Cadaveric Model. Spine. 2005 May 15;30(10):1165-1172.

16) Linville DA, Dmitriev AE. Lumbosacral Fixation: an Update. Current Opinion in Orthopaedics, 16(3) June 2005; 137-43.

17) McAfee PC, Cunningham BW, Holsapple G, Adams K, Blumenthal S, Guyer R, Dmitriev AE, Maxwell JH, Regan JJ, Isaza J. A prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: part II: evaluation of radiographic outcomes and correlation of surgical technique accuracy with clinical outcomes. Spine. 2005 Jul 15;30(14):1576-83.

18) Dmitriev AE, Kuklo TR. Biomechanical Considerations in the Aging Spine. Seminars in Spine Surgery. 2005 Sep; 17(3):215-222.

19) Kotani Y, Cunningham BW, Abumi K, Dmitriev AE, Hu N, Ito M, Shikinami Y, McAfee PC, Minami A. Multidirectional flexibility analysis of anterior and posterior lumbar artificial disc reconstruction: in vitro human cadaveric spine model. Eur Spine J, 2006.

20) Dmitriev AE, Kuklo TR, Lehman RA, Rosner MK. Stabilizing Potential Of Anterior, Posterior And Circumferential Fixation for Multilevel Cervical Arthrodesis. An In-Vitro Human Cadaveric Study Of The Operative And Adjacent Segment Kinematics. Spine. 2007 Mar 15;32(6):E188-96.

21) Chaput C, Patel K, Brindley, G, Roux M, Hu N, Dmitriev A, Cunningham B. Influence of a Platelet Concentrate on Prosthetic Bone Ingrowth in a Rabbit Model. J of Surg Ortho Adv, 2007 Winter;16(4):159-63.

22) Lehman RA, Sasso RC, Riew KD, Helgeson MD, Dmitriev AE, Gill NK, Rosner MK. Reliability of Intraoperative Plain Film Radiographs to Detect Violations of Intralaminar Screws Placed into the C2 Vertebrae. Spine. 2007 Dec 15; 32(26):3036-40.

23) Dmitriev AE, Gill NW, Rosner MK, Kuklo TR. The Effect of Two Level Lumbar Arthroplasty on Operative and Adjacent Segment Kinematics and Intradiscal Pressure. Spine J. 2008 Nov-Dec;8(6):918-25. Epub 2008 Jan 7.

24) Lehman RA, Jr., Dmitriev AE, Helgeson MD, Sasso RC, Riew KD. Salvage of C2 Pedicle and Pars Screws Using the Intralaminar Technique: A Biomechanical Analysis. Spine. 2008 Apr 20;33(9):960-5.

25) Kuklo TR, Dmitriev AE, Cardoso MJ, Gill NW, Erickson, Lehman RA. Biomechanical Contribution of Transverse Connectors to Segmental Stability Following Long Segment Instrumentation with Thoracic Pedicle Screws. Spine. 2008 Jul 1;33(15):E482-7.

26) Cardoso MJ, Dmitriev AE, Helgeson MD, Gill NW, Kuklo TR, Rosner MK, Lehman RA, Jr. Does Proximal Facet Violation With Intrapedicular Instrumentation Destabilize The Adjacent Level? An In-Vitro Human Cadaveric Assessment. Spine. 2008 Dec 15; 33(26):2868-73.

27) Cardoso MJ, Dmitriev AE, Lehman RA, Helgeson MD, Cooper P, Rosner MK. CT and Biomechanical Evaluation of Screw Fixation Options at the Cervicothoracic Junction: Intralamina vs. Intrapedicular Techniques. Spine. 2008 Nov 15;33(24):2612-7.

28) Wu X, Dmitriev AE, Cardoso MT, Veirs A, Anders J. 810 nm wavelength light: an effective therapy for transected or contused rat spinal cord. Lasers in Surgery and Medicine. 2009 Jan. 41:36-41.

29) Dmitriev AE, Lehman RA, Helgeson MD, Sasso RC, Riew DR. Acute and Long-Term Stability of Atlantoaxial Fixation Methods: A Biomechanical Comparison of Pars, Pedicle and Intralaminar Fixation in an Intact and Odontoid Fracture Model. Spine. 2009 Feb 15:34(4):365-70.

30) O’Brien JR, Dmitriev AE, Yu W, Gelb D, Ludwig S. Posterior-Only Stabilization of Two and Three Column Injury at the Cervicothoracic Junction: A Biomechanical Study. J of Spinal Disord. And Techn. J Spinal Disord Tech. 2009 Jul;22(5):340-6.

31) Cardoso MJ, Dmitriev AE, Helgeson MD, Stephens F, Campbell V, Lehman RA, Cooper P, Rosner MK. Using lamina screws as a salvage technique at C-7: computed tomography and biomechanical analysis using cadaveric vertebrae. Laboratory investigation. J Neurosurg Spine. 2009 Jul;11(1):28-33.

32) Kuklo TR, Dmitriev AE, Neal C, Brown A, Gill NW, Johnson T, Lehman RA. Does BMP-2 Overcome the Inhibitory Effects of Alendronate Sodium on Posterolateral Fusion Maturation in a Rabbit Model. In review.

33) Dmitriev AE, Farhang S, Lehman RA, Ling GSF, Symes AJ. BMP-2 Used in Spinal Fusion with Spinal Cord Injury Penetrates Intrathecally and Elicits a Functional Signaling Cascade. Spine Journal. Spine J. 2010 Jan;10(1):16-25. Epub 2009 Nov 14.

34) Tis JE, Helgeson M, Lehman RA, Dmitriev AE. A biomechanical comparison of different types of lumbopelvic fixation. Spine 2009 Nov 15;34(24):E866-72.

35) Lehman RA, Dmitriev AE, Cardoso MJ, Helgeson MD, Christensen C, Raymond J, Tobin E, Riew D. Effect of Teriparatide (rhPTH(34)) and Calcitonin on Intertransverse Process Fusion in a Rabbit Model. Spine 2010 Jan 15;35(2):146-52.

36) Cardoso MJ, Dmitriev AE, Helgeson MD, Paik H, Mendelsohn AK, Lehman RA, Rosner MK. Does catastrophic midline failure of upper thoracic lamina screws violate the spinal canal? A cadaveric biomechanical analysis using two laminar screw techniques. Spine J. 2010 Nov;10(11):1007-1013.

37) Dmitriev AE, Farhang S, Lehman RA, Ling GSF, Symes AJ. In a Rat Model of Spinal Arthrodesis and Spinal Cord Injury, rhBMP-2 Use Increases Gliosis and Intrathecal Inflammation And Alters Long-Term Functional Recovery. J Bone Joint Surg Am. 2011;93(16):1488-1499

38) Helgeson MD, Lehman RA, Patzkowski JC, Dmitriev AE, Rosner MK, Mack A. Adjacent Vertebral Body Osteolysis with Bone Morphogenetic Protein Use in Transforaminal Lumbar Interbody Fusion. Spine J. 2011 Jun;11(6):507-10

39) Helgeson MD, Lehman RA, Dmitriev AE, Sasso R, Riew D. Biomechanical Analysis of Occipitocervical Stability Afforded by Three Fixation Techniques. Spine J. 2011 Mar; 11(3):245-50.

40) Dmitriev AE, Lehman RA, Symes AJ. Bone Morphogenetic Protein-2 and Spinal Arthrodesis: The Basic Science Perspective on Protein Interaction with the Nervous System. Review. Spine J. 2011 Jun;11(6):500-5.

41) Lehman RA Jr, Helgeson MD, Dmitriev AE, Paik H, Bevevino AJ, Gaume R, Kang DG, Lenke LG. What is the best way to optimize thoracic kyphosis correction? A micro-CT and biomechanical analysis of pedicle morphology and screw failure. Spine. 2012 Sep 1; 37(19):E1171-6

42) Paik H, Dmitriev AE, Lehman RA, Ambati D, Gaume R. The biomechanical effect of pedicle screw hubbing on pullout resistance in the thoracic spine. Spine J. 2012 May; 12(5):417-24

43) Lehman RA Jr, Dmitriev AE, Wilson KW. Biomechanical analysis of C2 intralaminar fixation technique using a cross-link and offset connector for an unstable atlantoaxial joint. Spine J. 2012 Feb; 12(2):151-6

44) Paik H, Kang DG, Lehman RA, Gaume R, Ambati D, Dmitriev AE. The Biomechanical Consequences of Rod Reduction on Pedicle Screws: Should it be Avoided? Spine J. 2013 Nov; 13(11): 1617-26.

45) Paik H, Kang DG, Lehman RA Jr, Cardoso MJ, Gaume RE, Ambati DV, Dmitriev AE. Do stand-alone interbody spacers with integrated screws provide adequate segmental stability for multi-level cervical arthrodesis? Spine J. 2014 Jan 23

46) Kang DG, Lehman RA, Wagner SC, Bevevino AJ, Bernstock JD, Gaume R, Dmitriev AE. Pedicle screw re-insertion using previous pilot hole and trajectory does not reduce fixation strength. Spine J. 2014 in press.

47) Bevevino AJ, Lehman RA, Kang DG, Ambati D, Gaume R, Gwinn DE, Dmitriev AE. The effect of cervical posterior foraminotomy on segmental range of motion in the setting of total disc arthroplasty. Spine J. 2014 in press.

Professional Organizations

North American Spine Society