Siamak Ardekani is a member of the research faculty in the Department of Biomedical Engineering and Center for Imaging Science at Johns Hopkins University. With a background in medicine and medical imaging Ardekani focuses on developing computational models to extract clinically relevant information from medical images, generated through magnetic resonance imaging and computed tomography, that are used to quantify and visualize alterations in the shape and function of anatomical structures, such as the brain and heart. Models developed by Ardekani have the potential to assist physicians in identifying patients that are at a high risk of complications and monitor these patients’ responsiveness to therapy.

Ardekani earned his PhD in biomedical engineering from the University of California, Los Angeles, an MD from Shiraz University of Medical Sciences, and as MS in biomedical engineering from Drexel University. He has authored more than 20 research journals and conference papers in international journals and conference proceedings.

Education History

  • MS Biomedical Engineering, Drexel University
  • MD Medicine, Shiraz University of Medical Sciences
  • PhD Biomedical Engineering, University of California

Work Experience

Assistant Research Professor, Johns Hopkins University


1: Ardekani S, Jain S, Sanzi A, Corona-Villalobos CP, Abraham TP, Abraham MR,
Zimmerman SL, Wu KC, Winslow RL, Miller MI, Younes L. Shape analysis of
hypertrophic and hypertensive heart disease using MRI-based 3D surface models of
left ventricular geometry. Med Image Anal. 2016 Apr;29:12-23. doi:
10.1016/ PubMed PMID: 26766206; PubMed Central PMCID:

2: Ardekani S, Gunter G, Jain S, Weiss RG, Miller MI, Younes L. Estimating dense
cardiac 3D motion using sparse 2D tagged MRI cross-sections. Conf Proc IEEE Eng
Med Biol Soc. 2014;2014:5101-4. doi: 10.1109/EMBC.2014.6944772. PubMed PMID:
25571140; PubMed Central PMCID: PMC4474039.

3: Horsk√° A, Nidecker A, Intrapiromkul J, Tannazi F, Ardekani S, Brant LJ, Wharam
M Jr, Mahone EM. Diffusion tensor imaging of deep gray matter in children treated
for brain malignancies. Childs Nerv Syst. 2014 Apr;30(4):631-8. doi:
10.1007/s00381-013-2315-1. PubMed PMID: 24264381; PubMed Central PMCID:

4: Steinert-Threlkeld S, Ardekani S, Mejino JL, Detwiler LT, Brinkley JF, Halle
M, Kikinis R, Winslow RL, Miller MI, Ratnanather JT. Ontological labels for
automated location of anatomical shape differences. J Biomed Inform. 2012
Jun;45(3):522-7. doi: 10.1016/j.jbi.2012.02.013. PubMed PMID: 22490168; PubMed
Central PMCID: PMC3371096.

5: Tameem HZ, Ardekani S, Seeger L, Thompson P, Sinha US. Initial results on
development and application of statistical atlas of femoral cartilage in
osteoarthritis to determine sex differences in structure: data from the
Osteoarthritis Initiative. J Magn Reson Imaging. 2011 Aug;34(2):372-83. doi:
10.1002/jmri.22643. PubMed PMID: 21692138; PubMed Central PMCID: PMC3142327.

6: Ardekani S, Weiss RG, Lardo AC, Miller MI, Winslow RL, Younes L. Cardiac
Motion Analysis in Ischemic and Non-Ischemic Cardiomyopathy Using Parallel
Transport. Proc IEEE Int Symp Biomed Imaging. 2009 Jun:899. PubMed PMID:
20119497; PubMed Central PMCID: PMC2812909.

7: Ardekani S, Weiss RG, Lardo AC, George RT, Lima JA, Wu KC, Miller MI, Winslow
RL, Younes L. Computational method for identifying and quantifying shape features
of human left ventricular remodeling. Ann Biomed Eng. 2009 Jun;37(6):1043-54.
doi: 10.1007/s10439-009-9677-2. PubMed PMID: 19322659; PubMed Central PMCID:

8: Ardekani S, Kumar A, Bartzokis G, Sinha U. Exploratory voxel-based analysis of
diffusion indices and hemispheric asymmetry in normal aging. Magn Reson Imaging.
2007 Feb;25(2):154-67. PubMed PMID: 17275609.

9: Bui AA, Morioka C, Dionisio JD, Johnson DB, Sinha U, Ardekani S, Taira RK,
Aberle DR, El-Saden S, Kangarloo H. OpenSourcePACS: an extensible infrastructure
for medical image management. IEEE Trans Inf Technol Biomed. 2007
Jan;11(1):94-109. PubMed PMID: 17249408.

10: Ardekani S, Sinha U. Statistical representation of mean diffusivity and
fractional anisotropy brain maps of normal subjects. J Magn Reson Imaging. 2006
Dec;24(6):1243-51. PubMed PMID: 17083103.

11: Ardekani S, Selva L, Sayre J, Sinha U. Quantitative metrics for evaluating
parallel acquisition techniques in diffusion tensor imaging at 3 Tesla. Invest
Radiol. 2006 Nov;41(11):806-14. PubMed PMID: 17035871.

12: Ardekani S, Sinha U. Geometric distortion correction of high-resolution 3 T
diffusion tensor brain images. Magn Reson Med. 2005 Nov;54(5):1163-71. PubMed
PMID: 16187289.

13: Sinha U, Ardekani S. Parametric brain MR atlases: standardization for imaging
informatics. Stud Health Technol Inform. 2004;107(Pt 2):1374-8. PubMed PMID:

Professional Organizations

American Heart Association