Through lectures and team-projects, this course illustrates the fundamental design principles and applications of microfluidic system for biological and biomedical applications. Topics to be covered include issues associated with being in micrometers in science and engineering, fluid mechanics in micro systems, surface tension, wetting phenomena, electrokinetic phenomena in microscale. The course is not intended to provide students with extensive training in particular design and fabrication processes of such systems. However, students will learn to apply particular microfluidic object manipulation principle to design an innovative, conceptual microfluidic system. Undergraduate level of Fluid Mechanics and Thermodynamics and completion of a term project are required.