This course is intended for the physicist or engineer interested in the design of space experiments and space systems. The course presents the technical background, current state of the art, and example applications in the development of space systems. Topics include spacecraft thermal control, spacecraft configuration and structural design, space communications, risk analysis, command and telemetry systems, spacecraft computer systems, systems integration and test, and space mission operations. This course is team taught by experts in their respective fields. Prerequisite(s): An undergraduate degree in physics or engineering or the equivalent. Although preferable, it is not necessary to have taken EN.615.644 Physics of Space Systems I or EN.615.744 Physics of Space Systems I. Course Note(s): This course may be taken for 700-level credit with the additional requirement of a research paper. See EN.615.745 Fundamentals of Space Systems and Subsystems II.